Primary Amyloidosis, Paraproteinaemia and Neuropathy

Lymphoma, paraproteinaemia, and neuropathy.

Case presentation In 1984 a 55 year old former nurse developed anaemia (haemoglobin 6-4 g/dl), palpitation, haemoglobinuria, and splenomegaly. Investigations showed an erythrocyte sedimentation rate (ESR) > 140 mm/h, white blood cell count 4 x 109 g/l, platelets 97 x 109 g/l, reticulocytes 2-2%, direct Coombs test negative, anti-S antibody present; IgG 4-9 (7-19) g/l, IgA 0-6 (0 8-5) g/l, IgM 1...

IgG monoclonal paraproteinaemia and peripheral neuropathy.

Five patients with peripheral neuropathy and benign IgG monoclonal paraproteinemia are reported, all of whom had a sensorimotor neuropathy with a remitting and relapsing course. The serum paraprotein level did not correlate with the patient's clinical status. Electrophsyiological studies showed marked slowing of conduction velocity and conduction block in four of the patients and mild slowing i...

Peripheral neuropathy and benign IgG paraproteinaemia.

Three patients with peripheral neuropathy and an associated benign IgG paraproteinaemia are described. No direct immunological evidence for an aetiological role of the paraprotein was found, and the implications of this are discussed.

Neuropathy, amyloidosis, and monoclonal gammopathy.

Three cases of neuropathy with monoclonal gammopathy and amyloid deposits in peripheral nerves are described. They appeared to present a benign gammopathy because of the duration of the neuropathy in the absence of any clinical or biological sign of myeloma or macroglobulinaemia. The pathological abnormality found in the sural nerves of the three patients was characterised by a marked loss of m...

Familial amyloidosis with gastrointestinal neuropathy.